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1994-09-03
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Document 0126
DOCN M9490126
TI [CT and MRT in progressive multifocal leukoencephalopathy (PML)]
DT 9411
AU Lanfermann H; Heindel W; Schroder R; Lackner K; Institut und Poliklinik
fur Radiologische Diagnostik,; Universitat zu Koln.
SO Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr. 1994
Jul;161(1):38-43. Unique Identifier : AIDSLINE MED/94318837
AB Radiological findings and course of progressive multifocal
leukoencephalopathy in 14 patients (1 woman, 13 men; 13 HIV
seropositive, 1 chronic lymphatic leukaemia) were analysed
retrospectively and correlated with clinical symptoms. A total of 21 CT
and 16 MRI studies were evaluated. CT scans and MR images of 9 patients,
which had been obtained in less than two weeks, could be compared to
each other. MRI was superior to CT: 6 lesions with a diameter of 1 cm
and below were not detected on CT scans, in 5 patients the extent of
lesions was underestimated. Cortical involvement, mass effect or signs
of atrophy were missing. Only 1 of 67 lesions showed a tiny enhancement
after Gd injection. Due to the pattern and spread of lesions, which
showed a close correlation to the neurologic symptoms, three different
types of PML are suggested: 1. initial precentral demyelinisation with
contralateral hemiparesis (n = 8); 2. lesions in temporo-occipital
locations with visual disturbances (n = 2); 3. predominantly bilateral
lesions of cerebellar white matter with ataxia (n = 4).
DE Adult Biopsy Brain/PATHOLOGY Comparative Study English Abstract
Female Human HIV Seropositivity/COMPLICATIONS HIV-1/IMMUNOLOGY
Leukemia, Lymphocytic, Chronic/COMPLICATIONS Leukoencephalopathy,
Progressive Multifocal/*DIAGNOSIS/ EPIDEMIOLOGY/ETIOLOGY *Magnetic
Resonance Imaging Male Middle Age Retrospective Studies Time Factors
*Tomography, X-Ray Computed JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).